Ammonia → 9-(3-(2-(tert-Butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecane

HRID 471173노트

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HRID 471173 반응식
N.[Si:2]([O:9][CH2:10][CH2:11][C:12]1[C:13]([F:36])=[C:14]([CH:33]=[CH:34][CH:35]=1)[CH2:15][N:16]1[CH2:32][CH2:31][C:19]2([O:24][CH2:23][CH2:22][N:21](C(=O)C(F)(F)F)[CH2:20]2)[CH2:18][CH2:17]1)([C:5]([CH3:8])([CH3:7])[CH3:6])([CH3:4])[CH3:3]>CO>[Si:2]([O:9][CH2:10][CH2:11][C:12]1[C:13]([F:36])=[C:14]([CH:33]=[CH:34][CH:35]=1)[CH2:15][N:16]1[CH2:17][CH2:18][C:19]2([O:24][CH2:23][CH2:22][NH:21][CH2:20]2)[CH2:31][CH2:32]1)([C:5]([CH3:8])([CH3:6])[CH3:7])([CH3:4])[CH3:3]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 579890151-(9-(3-(2-(tert-Butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-2,2,2-trifluoroethanone

생성물 1

HCID 579891399-(3-(2-(tert-Butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecane

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

‘880’ Aqueous ammonia (3.0 mL) was added to stirred solution of 1-(9-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-2,2,2-trifluoroethanone (example 78, step c) (2.5 g) in MeOH (10 mL). After 1 h, the reaction mixture was evaporated to dryness. Acetonitrile was added, the solution was evaporated to dryness in vacuo, and the process repeated three times to give the subtitled compound as an oil. Yield 2.07 g. Used directly.

후처리

  1. customthe reaction mixture was evaporated to dryness
  2. additionAcetonitrile was added
  3. customthe solution was evaporated to dryness in vacuo

출처 및 근거

ORD 기록
ord-3b41524af0df49c98ad1da54e9568f5c
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629271B2

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