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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Tetrabutylammonium Fluoride → (2-Butylthiazol-4-yl)(9-(2-fluoro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone

HRID 471177
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인쇄 미리보기

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HRID 471177 반응식
CCCC[N+](CCCC)(CCCC)CCCC.[F-].[Si]([O:26][CH2:27][CH2:28][C:29]1[C:30]([F:58])=[C:31]([CH:55]=[CH:56][CH:57]=1)[CH2:32][N:33]1[CH2:54][CH2:53][C:36]2([O:41][CH2:40][CH2:39][N:38]([C:42]([C:44]3[N:45]=[C:46]([CH2:49][CH2:50][CH2:51][CH3:52])[S:47][CH:48]=3)=[O:43])[CH2:37]2)[CH2:35][CH2:34]1)(C(C)(C)C)(C)C>C1COCC1>[CH2:49]([C:46]1[S:47][CH:48]=[C:44]([C:42]([N:38]2[CH2:37][C:36]3([CH2:53][CH2:54][N:33]([CH2:32][C:31]4[CH:55]=[CH:56][CH:57]=[C:29]([CH2:28][CH2:27][OH:26])[C:30]=4[F:58])[CH2:34][CH2:35]3)[O:41][CH2:40][CH2:39]2)=[O:43])[N:45]=1)[CH2:50][CH2:51][CH3:52]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 57989198(9-(3-(2-(tert-Butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-butylthiazol-4-yl)methanone

생성물 1

HCID 57989168(2-Butylthiazol-4-yl)(9-(2-fluoro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

TBAF (1M solution in THF, 2.0 mL) was added to a solution of (9-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-butylthiazol-4-yl)methanone (example 78, step h) (0.350 g) in THF (4 mL). After 0.5 h, the solution was concentrated. Purification by silica gel chromatography eluting with 10:1 ethyl acetate; triethylamine gave the subtitled compound as a gum. Yield 0.24 g.

후처리

  1. concentrationthe solution was concentrated
  2. customPurification by silica gel chromatography
  3. washeluting with 10:1 ethyl acetate

출처 및 근거

ORD 기록
ord-ee5c48a391ce4fcabdd4fbe4bf8c98a8
출처 데이터셋
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08629271B2

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