2-(2-Chloro-3-(hydroxymethyl)phenyl)ethanol → 2-Chloro-3-(2-hydroxyethyl)benzaldehyde
반응식
[Cl:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:10][CH2:11][OH:12]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[C:3]([CH2:10][CH2:11][OH:12])=[CH:4][CH:5]=[CH:6][C:7]=1[CH:8]=[O:9]참가 물질
4
실험 절차
Manganese (IV) dioxide (1.599 g) was added to a solution of 2-(2-chloro-3-(hydroxymethyl)phenyl)ethanol (example 80, step c) (0.342 g) in DCM (20 mL), and the resulting suspension was stirred at room temperature overnight. The mixture was then concentrated onto silica and purified by flash chromatography on silica eluted with 25% ethyl acetate in isohexane to afford the subtitled compound as a white crystalline solid. Yield 0.223 g.
후처리
- concentrationThe mixture was then concentrated onto silica
- custompurified by flash chromatography on silica
- washeluted with 25% ethyl acetate in isohexane
출처 및 근거
- ORD 기록
- ord-025684fe684d4dc29f0e5f9c4b359b8e
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08629271B2
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