Ethanol → 4-Dodecyl-2-nitroaniline

HRID 4713노트

반응식

HRID 4713 반응식
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:7][C:6]=1[N+:23]([O-:25])=[O:24])(=O)C.C(O)C.[OH-].[K+]>O>[CH2:11]([C:8]1[CH:9]=[CH:10][C:5]([NH2:4])=[C:6]([N+:23]([O-:25])=[O:24])[CH:7]=1)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 14122183N-acetyl-4-n-dodecyl-2-nitroaniline

생성물 1

HCID 141221844-Dodecyl-2-nitroaniline

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In a 1-liter flask fitted with a stirrer and reflux condenser, 61.8 grams of N-acetyl-4-n-dodecyl-2-nitroaniline (prepared in Example 2b), 320 ml of ethanol and 64 ml of 40% aqueous potassium hydroxide solution are heated for 1 hour under reflux. The reaction mixture is cooled and then poured into 1.5 liters of water. The crude product is isolated by filtration, washed repeatedly with cold water and recrystallized from methanol. The above-named product is isolated as a solid melting at 69°-71° C. in a yield of 45 grams.

후처리

  1. customIn a 1-liter flask fitted with a stirrer
  2. temperaturereflux condenser
  3. temperatureunder reflux
  4. temperatureThe reaction mixture is cooled
  5. customThe crude product is isolated by filtration
  6. washwashed repeatedly with cold water
  7. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-988f9d1f7f0e4e7b89b7025738b61397
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727158

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