참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Ethyl chloroacetate | HCID 7751 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Diethyl 2-(benzyloxycarbonylamino)malonate | HCID 259787 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Diethyl 2-benzyloxycarbonylamino-2-ethoxycarbonylsuccinate | HCID 66725114 | 86.1% |
반응 단계
A suspension of diethyl 2-benzyloxycarbonylaminomalonate (5.0 g), potassium carbonate (2.7 g), potassium iodide (0.27 g), and ethyl 2-chloroacetate (2.6 g) in DMF (50 mL) was stirred at 50° C. for 1 hour. The reaction mixture was cooled, and then poured into diluted hydrochloric acid, the mixture was extracted with ethyl acetate, and the extract was washed with saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was crystallized from ethyl acetate/n-hexane to obtain the title compound (5.5 g, yield: 86%) as colorless crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08633001B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_01 |
|---|
| ORD ID | ord-4f8c0cee62264453a4179fbdc751226d |
|---|
| 출처 메모 | uspto-grants-2014_01 |
|---|
