참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 6-ethyl-5-iodo-1H-pyrimidin-4-one | HCID 178437744 | — |
| 생성물 | 4-Chloro-6-ethyl-5-iodopyrimidine | HCID 10978487 | — |
반응 단계
A suspension of 90 g (0.36 mol) 4-hydroxy-5-iodo-6-ethyl pyrimidine in 600 mL POCl3 is heated for 1 h at 90° C. The reaction mixture is concentrated under reduced pressure and the residue is poured into crushed ice. The precipitated solid is collected by filtration and washed with water. After drying, the desired product is obtained as a solid (65 g; 67%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08633183B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_01 |
|---|
| ORD ID | ord-6cd1afec87c74639a86a29cbb8cdcfc3 |
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| 출처 메모 | uspto-grants-2014_01 |
|---|
