Benzyl Bromide → 4-Benzyloxy-2-methoxybenzaldehyde

HRID 471428

반응식

HRID 471428 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([O:10][CH3:11])[CH:3]=1.[CH2:12](Br)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:12]([O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([O:10][CH3:11])[CH:3]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 5195414-Hydroxy-2-Methoxybenzaldehyde

생성물 1

HCID 42939904-Benzyloxy-2-methoxybenzaldehyde수율 62.8%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

4-Hydroxy-2-methoxybenzaldehyde (2.0 g, 13.15 mmol), benzyl bromide (3.14 mL, 26.3 mmol) and potassium carbonate (3.63 g, 26.3 mmol) are combined in acetone (5 mL) and the mixture is stirred for 4 hours. The mixture is concentrated under vacuum, suspended in dichloromethane and washed with water. The organic phase is concentrated under vacuum and the residue purified by flash chromatography (10% ethyl acetate in cyclohexane) to give the title compound (yield 2.0 g).

후처리

  1. concentrationThe mixture is concentrated under vacuum
  2. washwashed with water
  3. concentrationThe organic phase is concentrated under vacuum
  4. customthe residue purified by flash chromatography (10% ethyl acetate in cyclohexane)

출처 및 근거

ORD 기록
ord-261053784076497a937144debb75293a
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08633182B2

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