4-Nitro-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide → 4-amino-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide

HRID 471442노트

반응식

HRID 471442 반응식
[N+:1]([C:4]1[C:17]([CH3:18])=[CH:16][C:7]([C:8]([NH:10][CH2:11][C:12]([OH:15])([CH3:14])[CH3:13])=[O:9])=[CH:6][C:5]=1[CH3:19])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[C:5]([CH3:19])=[CH:6][C:7]([C:8]([NH:10][CH2:11][C:12]([OH:15])([CH3:13])[CH3:14])=[O:9])=[CH:16][C:17]=1[CH3:18]

참가 물질

4

반응물 1

HCID 867038834-Nitro-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide

생성물 1

HCID 867038844-amino-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide수율 84.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

4-Nitro-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide (1.2 g, 4.51 mmol) is suspended in methanol (10 mL) and hydrogenated at 3 bar for 3 hours using 10% palladium on activated carbon (120 mg) as the catalyst. The mixture is filtered through celite and the solvent removed under vacuum to give the title compound (Yield 900 mg).

후처리

  1. filtrationThe mixture is filtered through celite
  2. customthe solvent removed under vacuum

출처 및 근거

ORD 기록
ord-67c5733925104d7ca320afd798f14b04
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08633182B2

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