N,3,5-Trimethyl-4-nitrobenzamide → 4-amino-N,3,5-trimethylbenzamide

HRID 471447노트

반응식

HRID 471447 반응식
[N+:1]([C:4]1[C:13]([CH3:14])=[CH:12][C:7]([C:8]([NH:10][CH3:11])=[O:9])=[CH:6][C:5]=1[CH3:15])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[C:5]([CH3:15])=[CH:6][C:7]([C:8]([NH:10][CH3:11])=[O:9])=[CH:12][C:13]=1[CH3:14]

참가 물질

4

반응물 1

HCID 86697180N,3,5-Trimethyl-4-nitrobenzamide

생성물 1

HCID 668742744-amino-N,3,5-trimethylbenzamide수율 99.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

4-Nitro-3,5,N-trimethyl-benzamide (1.0 g, 4.8 mmol) is suspended in methanol (10 mL) and hydrogenated at 3 bar for 3 hours using 10% Palladium on activated carbon (100 mg) as the catalyst. The mixture is filtered through celite and the solvent removed under vacuum to give the title compound (Yield 850 mg).

후처리

  1. filtrationThe mixture is filtered through celite
  2. customthe solvent removed under vacuum

출처 및 근거

ORD 기록
ord-4c035677036649519800a4b9ee9957a0
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08633182B2

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