m-Chloroperbenzoic acid → HCID 67400511, 화합물

HRID 471575노트

반응식

HRID 471575 반응식
[S:1]([NH:5][C:6]1[CH:13]=[CH:12][CH:11]=[C:10]([S:14][CH3:15])[C:7]=1[C:8]#[N:9])(=[O:4])(=[O:3])[NH2:2].C1C=C(Cl)C=C(C(OO)=[O:24])C=1>ClCCl>[S:1]([NH:5][C:6]1[CH:13]=[CH:12][CH:11]=[C:10]([S:14]([CH3:15])=[O:24])[C:7]=1[C:8]#[N:9])(=[O:3])(=[O:4])[NH2:2]

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 67400359HCID 67400359, 화합물

생성물 1

HCID 67400511HCID 67400511, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The mixture of 2-sulfamoylamino-6-(methylthio)benzonitrile (Example 104a) (48 mg, 0.2 mmol) and MCPBA (69 mg, 0.4 mmol) in dichloromethane (16 mL) was heated refluxed overnight. After cooling down, the precipitation was collected by filtration, rinsed with dichloromethane, dried in the air to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ 2.83 (s, 3H), 7.35 (brs, 2H), 7.72-6.69 (m, 2H), 7.92 (t, J=8.0 Hz, 1H), 9.87 (brs, 1H).

후처리

  1. temperaturewas heated
  2. temperaturerefluxed overnight
  3. temperatureAfter cooling down
  4. customthe precipitation
  5. filtrationwas collected by filtration
  6. washrinsed with dichloromethane
  7. customdried in the air

출처 및 근거

ORD 기록
ord-741907e5e3124b75b0c41e025ae2a1c3
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08633186B2

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