2-Bromopropane → 2-Nitro-6-isopropoxybenzonitrile

HRID 471585노트

반응식

HRID 471585 반응식
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:3]=1[C:4]#[N:5].[CH:13](Br)([CH3:15])[CH3:14]>>[N+:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:2]([O:1][CH:13]([CH3:15])[CH3:14])[C:3]=1[C:4]#[N:5])([O-:12])=[O:11]

참가 물질

3

반응물 2

HCID 63582-BromopropaneHCID 125032052-Hydroxy-6-nitrobenzonitrile

생성물 1

HCID 127157832-Nitro-6-isopropoxybenzonitrile수율 64%

실험 절차

Prepared in a similar manner as Example 115c from 2-hydroxy-6-nitrobenzonitrile (Example 115d) and isopropyl bromide to provide 2-nitro-6-isopropoxybenzonitrile (324 mg, 64%). 1H NMR (400 MHz, MeOD) 61.43 (d, J=6.2 Hz, 6H), 4.89 (sept, J=6.2 Hz, 1H), 7.61 (dd, J=8.0, 1.0 Hz, 1H), 7.80 (t, J=8.2 Hz, 1H), 7.85 (dd, J=8.2, 1.2 Hz, 1H).

출처 및 근거

ORD 기록
ord-1caf18da88f7432b935957e851f70c77
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08633186B2

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