Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide dimethyl acetal → 3-Dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 반응물 | 2,4-Dimethyl-5-acetylthiazole | HCID 520888 | — |
| 생성물 | 3-Dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone | HCID 91621644 | 79% |
반응 단계
A solution of 5-acetyl-2,4-dimethylthiazole (10 g, 60 mmol) in N,N-dimethylformamide dimethylacetal (10 mL) was refluxed under N2. After 18 h, the reaction mixture was evaporated to dryness and the residue was recrystallised from iPr2O/CH2Cl2 to afford the title compound as a brown powder (9.94 g, 79%). 1H-NMR (300 MHz, CDCl3) δ2.66 (s, 6H, CH3), 2.70 (s, 6H, CH3), 5.37 (d, 1H, J=12.2 Hz, CH), 7.66 (d, 1H, J=12.2 Hz, CH).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06699854B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-956af8e832b341b9a97d2cec1966f362 |
| 출처 메모 | uspto-grants-2004_03 |