Quinuclidine → n-DODECANOYLOXYMETHYLQUINUCLIDINIUM CHLORIDE

HRID 4720

반응식

HRID 4720 반응식
[C:1]([O:14][CH2:15][Cl:16])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[N:17]12[CH2:24][CH2:23][CH:20]([CH2:21][CH2:22]1)[CH2:19][CH2:18]2.[K+].[Br-]>CCOCC>[Cl-:16].[C:1]([O:14][CH2:15][N+:17]12[CH2:24][CH2:23][CH:20]([CH2:21][CH2:22]1)[CH2:19][CH2:18]2)(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

참가 물질

5

반응물 3

HCID 7527QuinuclidineHCID 253877Potassium BromideHCID 543634Chloromethyl dodecanoate

생성물 1

HCID 14128213n-DODECANOYLOXYMETHYLQUINUCLIDINIUM CHLORIDE

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

2.49 g (0.01 mol) chloromethyl n-dodecanoate and 1.12 g (0.01 mol) quinuclidine were mixed and allowed to react together at room temperature for 48 hrs. Anhydrous ether was added to the mixture and the mixture was triturated in anydrous ether overnite. The solid was isolated by filtration under a nitrogen atmosphere and thoroughly washed with anhydrous ether. After drying in vacuo over calcium sulfate at room temperature, 2.1 g (0.006 mol), 17 was obtained as a white solid, mp 170°-172°; ir (KBr) 2960, 2930, 1765, 1470, 1120, 1090, 860 and 830 cm-1 ; pmr (CDCl3) δ 5.8 (s, 2H), 3.9 (t, 6H), 2.5 (t, 2H), 2.2 (m, 7H), 1.3 (bs, 18H) and 0.9 (t, 3H) ppm.

후처리

  1. customto react together at room temperature for 48 hrs
  2. customthe mixture was triturated in anydrous ether overnite
  3. customThe solid was isolated by filtration under a nitrogen atmosphere
  4. washthoroughly washed with anhydrous ether
  5. dry with materialAfter drying in vacuo over calcium sulfate at room temperature
  6. custom2.1 g (0.006 mol), 17 was obtained as a white solid, mp 170°-172°

출처 및 근거

ORD 기록
ord-fa1c20f388e948989dd21b012d79f7a9
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727151

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