3-Ethoxy-2-propenoyl chloride → HCID 67205344, 화합물

HRID 472159

반응식

HRID 472159 반응식
[CH3:1][C:2]1[N:3]=[CH:4][N:5]([C:7]2[CH:13]=[CH:12][C:10]([NH2:11])=[CH:9][CH:8]=2)[CH:6]=1.[CH2:14]([O:16][CH:17]=[CH:18][C:19](Cl)=[O:20])[CH3:15]>N1C=CC=CC=1>[CH2:14]([O:16][CH:17]=[CH:18][C:19]([NH:11][C:10]1[CH:12]=[CH:13][C:7]([N:5]2[CH:6]=[C:2]([CH3:1])[N:3]=[CH:4]2)=[CH:8][CH:9]=1)=[O:20])[CH3:15]

참가 물질

4

반응물 2

HCID 30144293-Ethoxy-2-propenoyl chlorideHCID 160051704-(4-Methyl-1h-imidazol-1-yl)benzenamine

생성물 1

HCID 67205344HCID 67205344, 화합물수율 75%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
0 °C

실험 절차

4-(4-methyl-1H-imidazol-1-yl)aniline (15 g, 138 mmol) was dissolved in dry pyridine (80 mL), freshly distilled 3-ethoxyacryloyl chloride (19 g, 140 mmol) was then added drop-wise at 5°/0° C. The resulting mixture was stirred at 0° C. for 1 hours and at r.t. overnight. The reaction mixture was quenched with water (500 mL), the pH was adjusted to pH=10, by adding K2CO3 and the resulting solid was filtered, washed with water and dried, to provide the title product as slight orange powder (18.6 g; 75%), m.p.: 214-216° C. C15H17N3O2, MW: 271.32.

후처리

  1. customThe reaction mixture was quenched with water (500 mL)
  2. additionby adding K2CO3
  3. filtrationthe resulting solid was filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-70d0fd609848416c9eb2ed7ffc069626
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08633208B2

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