Sodium ethoxide → 3-Ethoxymethyl-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole

HRID 47220노트

반응식

I[CH2:2][C:3]1[N:7]=[C:6]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][C:13]=2[C:14]([F:17])([F:16])[F:15])[O:5][N:4]=1.[O-:18][CH2:19][CH3:20].[Na+]>>[CH2:19]([O:18][CH2:2][C:3]1[N:7]=[C:6]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][C:13]=2[C:14]([F:17])([F:16])[F:15])[O:5][N:4]=1)[CH3:20]

참가 물질

반응물 2

HCID 2723922Sodium ethoxide

HCID 227440943-Iodomethyl-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole

생성물 1

HCID 97955013-Ethoxymethyl-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole

실험 절차

3-Iodomethyl-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole (0.5 g) was dissolved in a freshly prepared solution of sodium ethoxide (30 mg of sodium in 7 ml of ethanol), and the mixture was stirred at room temperature for 6 hours.

출처 및 근거

ORD 기록: ord-dcd801376dc94a32b1b20d493cbefdc7
출처 데이터셋: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06699853B2

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