Benzaldehyde, 4-hydroxy-3-methoxy-2-nitro- → HCID 136397840, 화합물

HRID 47267노트

반응식

HRID 47267 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[O:13][CH3:14].[NH:15]([C:17]1[CH:22]=[CH:21][C:20]([C:23]2[C@H:24]([CH3:30])[CH2:25][C:26](=[O:29])[NH:27][N:28]=2)=[CH:19][CH:18]=1)[NH2:16]>C(O)C>[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[N:16][NH:15][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[C@H:24]([CH3:30])[CH2:25][C:26](=[O:29])[NH:27][N:28]=3)=[CH:19][CH:18]=2)=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[O:13][CH3:14]

참가 물질

4

반응물 2

HCID 96959Benzaldehyde, 4-hydroxy-3-methoxy-2-nitro-HCID 69529174(R)-6-(4-hydrazino-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one

생성물 1

HCID 136397840HCID 136397840, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A solution of 4-hydroxy-3-methoxy-2-nitro-benzaldehyde (1.6 g) in ethanol (15 ml) was added to a suspension of (R)-6-(4-hydrazino-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one (1.75 g) in ethanol (20 ml) and the resulting mixture refluxed for two hours. The resulting crystals were filtered at room temperature and washed with ethanol. Yield 2.37 g. HPLC: purity 99.4%, optical purity 99.8%.

후처리

  1. temperaturethe resulting mixture refluxed for two hours
  2. filtrationThe resulting crystals were filtered at room temperature
  3. washwashed with ethanol

출처 및 근거

ORD 기록
ord-b9d0cf976a794ddeb6ba1b5f4e6d51f5
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699868B2

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