Dimethylformamide → 2-Dimethylaminomethyl-9-methoxy-4H-thieno[2,3-c]isoquinolin-5-one

HRID 472673

반응식

HRID 472673 반응식
[CH3:1][O:2][C:3]1[C:4]2[C:5]3[CH:16]=[CH:15][S:14][C:6]=3[NH:7][C:8](=[O:13])[C:9]=2[CH:10]=[CH:11][CH:12]=1.[Cl-].CC=[N+]=CC.[CH3:23][N:24]([CH:26]=O)[CH3:25]>C(#N)C>[CH3:23][N:24]([CH2:26][C:15]1[S:14][C:6]2[NH:7][C:8](=[O:13])[C:9]3[CH:10]=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[C:4]=3[C:5]=2[CH:16]=1)[CH3:25]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 99646519-methoxy-4H-thieno[2,3-c]isoquinolin-5-oneHCID 21873455N,N-dimethylmethylene ammonium chloride

생성물 1

HCID 446006712-Dimethylaminomethyl-9-methoxy-4H-thieno[2,3-c]isoquinolin-5-one

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

9-Methoxy-4H-thieno[2,3-c]isoquinolin-5-one (12.7 g; 54.9 mmol) and N,N-dimethylmethyleneammonium chloride (8.53 g; 91.14 mmol) were placed in a 0.5 L three neck round bottle flask under nitrogen atmosphere. Under stirring, DMF (75 mL) was added followed by acetonitrile (ACN) (190 mL) and the reaction mixture was placed into a preheated oil bath (90° C.). The reaction was complete after 1.5 hrs indicated by a worked up NMR sample.

후처리

  1. customthe reaction mixture was placed into a preheated oil bath
  2. custom(90° C.)

출처 및 근거

ORD 기록
ord-e4b73de79cac4ea686e1f4e04e131a11
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08633215B2

연결된 노트

불러오는 중…