HCID 86641478, 화합물 → {5-Chloro-1-[(5-chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-pyrido[4,3-d]pyrimidin-3-yl}-acetic acid

HRID 472739노트

반응식

HRID 472739 반응식
C([O:5][C:6](=[O:36])[CH2:7][N:8]1[C:13](=[O:14])[C:12]2[C:15]([Cl:19])=[N:16][CH:17]=[CH:18][C:11]=2[N:10]([CH2:20][C:21](=[O:34])[NH:22][C:23]2[CH:28]=[C:27]([Cl:29])[C:26]([O:30][CH3:31])=[CH:25][C:24]=2[O:32][CH3:33])[C:9]1=[O:35])(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[Cl:19][C:15]1[C:12]2[C:13](=[O:14])[N:8]([CH2:7][C:6]([OH:36])=[O:5])[C:9](=[O:35])[N:10]([CH2:20][C:21](=[O:34])[NH:22][C:23]3[CH:28]=[C:27]([Cl:29])[C:26]([O:30][CH3:31])=[CH:25][C:24]=3[O:32][CH3:33])[C:11]=2[CH:18]=[CH:17][N:16]=1

참가 물질

4

반응물 1

HCID 86641478HCID 86641478, 화합물2회

생성물 1

HCID 59317708{5-Chloro-1-[(5-chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-pyrido[4,3-d]pyrimidin-3-yl}-acetic acid

시약·촉매·용매 2

HCID 6344Dichloromethane용매2회HCID 6422Trifluoroacetic acid용매

실험 절차

To a vial containing a solution of {5-Chloro-1-[(5-chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-pyrido[4,3-d]pyrimidin-3-yl}-acetic acid tert-butyl ester (Intermediate T) (10.1 mg, 0.019 mmol) in DCM (1 ml), TFA (1 ml) is added. The reaction mixture is stirred at RT for 2 hours, transferred to a 10 ml round bottomed flask, diluted with a minimal amount of DCM and concentrated in vacuo. The residue is taken up in a minimal amount of DCM and concentrated in vacuo. This process is repeated once with DCM, twice with EtOAc, and once with MeOH, the solvent being concentrated in vacuo each time, finally giving the title compound.

후처리

  1. additionis added
  2. customtransferred to a 10 ml round bottomed flask
  3. concentrationconcentrated in vacuo
  4. concentrationconcentrated in vacuo
  5. concentrationonce with MeOH, the solvent being concentrated in vacuo each time

출처 및 근거

ORD 기록
ord-f4fcef4606b445939faef957f9cb1d05
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08633211B2

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