Dichloromethane → 2-[4-(2-Methanesulfonyloxy-ethyl)-phenyl]-2-methyl-propionic acid ethylester

HRID 472799노트

반응식

HRID 472799 반응식
[CH2:1]([O:3][C:4](=[O:17])[C:5]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[CH:10][CH:9]=1)([CH3:7])[CH3:6])[CH3:2].C(N(CC)CC)C.[CH3:25][S:26](Cl)(=[O:28])=[O:27].ClCCl>O>[CH2:1]([O:3][C:4](=[O:17])[C:5]([C:8]1[CH:9]=[CH:10][C:11]([CH2:14][CH2:15][O:16][S:26]([CH3:25])(=[O:28])=[O:27])=[CH:12][CH:13]=1)([CH3:7])[CH3:6])[CH3:2]

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 66869809Ethyl 2-(4-(2-hydroxyethyl)phenyl)-2-methylpropanoate

생성물 1

HCID 866497982-[4-(2-Methanesulfonyloxy-ethyl)-phenyl]-2-methyl-propionic acid ethylester수율 109.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In a reaction vessel, 2-[4-(2-hydroxy-ethyl)-phenyl]-2-methyl-propionic acid ethylester (2.2 g) prepared in the Example 4, triethylamine (1.2 g), methanesulfonylchloride (1.25 g) and dichloromethane (20 mL) were introduced, and the mixture was reacted at room temperature for 2 hours. Distilled water (50 mL) was added thereto, and the mixture was stirred to separate layers. The separated organic layer was dehydrated with Na2SO4, and then condensed by filtration to obtain 2-[4-(2-methanesulfonyloxy-ethyl)-phenyl]-2-methyl-propionic acid ethylester (3.2 g, yield 100%).

후처리

  1. additionwere introduced
  2. customthe mixture was reacted at room temperature for 2 hours
  3. customto separate layers
  4. customcondensed
  5. filtrationby filtration

출처 및 근거

ORD 기록
ord-9c387225fd574240bce7bc36f0352e0c
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08633223B2

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