Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-[2-(Hydroxymethyl)phenyl]ethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Homophthalic acid | HCID 66643 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-[2-(Hydroxymethyl)phenyl]ethanol | HCID 239024 | 80% |
반응 단계
To a solution of 2-(carboxymethyl)benzoic acid (9 g, 0.05 mol) in THF (200 mL) was added to LAH in THF (250 mL) dropwise, the mixture was refluxed for 18 hours. The mixture was cooled in ice bath and carefully added water dropwise, followed by 50% NaOH (150 mL), then removed the ice bath and added water slowly with stirring until the gray precipitate turns white. The mixture was filtrated and the filtrate was concentrated to give crude 2-(2-(hydroxymethyl)phenyl)ethanol (6 g, 80%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08633212B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-efec38a8c2c74880b1bcd89041d94028 |
| 출처 메모 | uspto-grants-2014_01 |