Potassium Hydroxide → 2-(4-Bromobenzyl)malonic acid
반응식
[Br:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][CH:7]([C:13]([O:15]CC)=[O:14])[C:8]([O:10]CC)=[O:9])=[CH:4][CH:3]=1.[OH-].[K+]>OC(C)=O.O.C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]([C:8]([OH:10])=[O:9])[C:13]([OH:15])=[O:14])=[CH:18][CH:19]=1참가 물질
4
실험 절차
Diethyl 2-(4-bromobenzyl)malonate (40 g, 13 mmol) and KOH (42.8 g, 76 mmol) was dissolved in a mixture of HOAc-H2O-THF (1:2:3, 200 mL), the mixture was refluxed for 12 hours. The solvent was removed in vacuo, the residue was added HCl aqueous, then extracted with EtOAc, washed with brine, dried over Na2SO4, concentrated to give 2-(4-bromobenzyl)malonic acid (31 g, 95%).
후처리
- temperaturethe mixture was refluxed for 12 hours
- customThe solvent was removed in vacuo
- additionthe residue was added HCl aqueous
- extractionextracted with EtOAc
- washwashed with brine
- dry with materialdried over Na2SO4
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-01c7f3098df2413bb1bdfff583d7c8cd
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08633212B2
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