1,8-Diazabicyclo(5.4.0)undec-7-ene → 1-Chloro-4-[(3-chloro-4-methylbenzyl)amino]-6-phthalazinecarbonitrile

HRID 47305노트

반응식

HRID 47305 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]#[N:13])=[CH:9][CH:10]=2)[C:5](Cl)=[N:4][N:3]=1.[Cl:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][C:23]=1[CH3:24])[CH2:19][NH2:20].C1CCN2C(=NCCC2)CC1>CN1CCCC1=O>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]#[N:13])=[CH:9][CH:10]=2)[C:5]([NH:20][CH2:19][C:18]2[CH:21]=[CH:22][C:23]([CH3:24])=[C:16]([Cl:15])[CH:17]=2)=[N:4][N:3]=1

참가 물질

5

반응물 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 106225Benzenemethanamine, 3-chloro-4-methyl-HCID 106567381,4-Dichlorophthalazine-6-carbonitrile

생성물 1

HCID 183746191-Chloro-4-[(3-chloro-4-methylbenzyl)amino]-6-phthalazinecarbonitrile

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

1,4-Dichlorophthalazine-6-carbonitrile and 3-chloro-4-methylbenzylamine were stirred at room temperature in 1-methyl-2-pyrrolidinone in the presence of DBU, whereby the title compound was obtained as a less polar compound.

출처 및 근거

ORD 기록
ord-6bbd4910440449faafa0c8e9303aefc7
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699870B2

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