Potassium Carbonate → (S)-N-(5-((2-(trifluoromethyl)phenoxy)methyl)-2,3-dihydro-1H-inden-2-yl)propane-2-sulfonamide

온도

120 °C

A mixture of potassium carbonate (0.174 mmol, 24.01 mg), 2-(trifluoromethyl)phenol (0.087 mmol, 14.08 mg), and (S)-N-(5-(chloromethyl)-2,3-dihydro-1H-inden-2-yl)propane-2-sulfonamide (0.087 mmol, 25 mg) in DMF (2 mL) was heated at 120° C. for 900 s in a Smith Synthesiser microwave. The reaction mixture was concentrated to dryness before DCM (2 mL) and H2O (2 mL) was added and the reaction mixture filtered through a hydrophobic frit washing with further DCM (2 mL). The DCM layer was concentrated to dryness and purified by preparative HPLC to furnish the desired product (10.0 mg, 27.8%). MS (ESI): m/z [M−H]− 412.2

1. concentrationThe reaction mixture was concentrated to dryness before DCM (2 mL) and H2O (2 mL)
2. additionwas added
3. filtrationthe reaction mixture filtered through a hydrophobic frit
4. washwashing with further DCM (2 mL)
5. concentrationThe DCM layer was concentrated to dryness
6. custompurified by preparative HPLC

ORD 기록

ord-5292ea96289149bfbd9b3cb14c3da606

출처 데이터셋

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08633237B2