Sodium Bicarbonate → 7-[1-(1,1-dimethylethyl)-1H-pyrazol-4-yl]-N-{[(3S)-3-fluoro-3-piperidinyl]methyl}-1,6-naphthyridin-5-amine dihydrochloride

반응식

[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[C:4]([NH:12][CH2:13][C@:14]2([F:27])[CH2:19][CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]2)[N:3]=1.[CH3:28][C:29]([N:32]1[CH:36]=[C:35](B2OC(C)(C)C(C)(C)O2)[CH:34]=[N:33]1)([CH3:31])[CH3:30].C(=O)(O)[O-].[Na+]>O1CCOCC1.O.[Pd](Cl)Cl.C(P(C(C)(C)C)[C-]1C=CC=C1)(C)(C)C.[C-]1(P(C(C)(C)C)C(C)(C)C)C=CC=C1.[Fe+2]>[ClH:1].[ClH:1].[CH3:28][C:29]([N:32]1[CH:36]=[C:35]([C:2]2[N:3]=[C:4]([NH:12][CH2:13][C@:14]3([F:27])[CH2:19][CH2:18][CH2:17][NH:16][CH2:15]3)[C:5]3[CH:6]=[CH:7][CH:8]=[N:9][C:10]=3[CH:11]=2)[CH:34]=[N:33]1)([CH3:31])[CH3:30]