Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydroxyamine hydrochloride → 4,6-Dichloro-5-pyrimidinecarbaldehyde oxime
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 반응물 | 4,6-Dichloro-5-pyrimidinecarbaldehyde | HCID 819691 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4,6-Dichloro-5-pyrimidinecarbaldehyde oxime | HCID 76016516 | — |
반응 단계
A mixture of 4,6-dichloro-5-pyrimidinecarbaldehyde (8.00 g, 44.8 mmol), NaOAc (3.7 g, 1.0 eq) and NH2OH.HCl (3.1 g, 1.0 eq) in EtOH (320 mL) was stirred at rt for 2 h. The reaction mixture was filtered, concentrated and purified by column chromatography on silica gel (dry loading, first DCM then DCM/EtOAc, 1/9) to give 4,6-dichloro-5-pyrimidinecarbaldehyde oxime as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08633313B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-64dbeddf322143e9b88c95063bb18c7e |
| 출처 메모 | uspto-grants-2014_01 |