Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 473427생성일: 2026년 10월 26일
Cerium trichloride heptahydrate → Methyl 7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate
https://huagongshe.com/reaction/473427
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cerium trichloride heptahydrate | HCID 21585214 | — |
| 반응물 | Methyl 3-(2-(methylsulfonyl)phenyl)-3-oxopropanoate | HCID 58318596 | — |
| 반응물 | 3-Amino-5-fluoropyridine-2-carbaldehyde | HCID 58318647 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Methyl 7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate | HCID 67239501 | — |
반응 단계
A mixture of 3-amino-5-fluoropicolinaldehyde (930 mg, 6.63 mmol), methyl 3-(2-(methylsulfonyl)phenyl)-3-oxopropanoate (1.7 g, 6.63 mmol) and cerium chloride heptahydrate (435 mg, 1.32 mmol) was heated to 100° C. for 3 h. The residue was dissolved in MeOH and purified by column chromatography on neutral alumina using 0-30% EtOAc in hexane to give methyl 7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate: LC-MS (ESI) m/z 361.0 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08633313B2 |
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| 출처 데이터셋 | uspto-grants-2014_01 |
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| ORD ID | ord-dcebcd8a05e140ac8c25b09b70a04a8f |
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| 출처 메모 | uspto-grants-2014_01 |
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