3-Nitropicolinaldehyde → 3-Aminopyridine-2-carbaldehyde

HRID 473434

반응식

HRID 473434 반응식
[N+:1]([C:4]1[C:5]([CH:10]=[O:11])=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O>CCO.[Pd]>[NH2:1][C:4]1[C:5]([CH:10]=[O:11])=[N:6][CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 1

HCID 3293613-Nitropicolinaldehyde

생성물 1

HCID 122040093-Aminopyridine-2-carbaldehyde수율 50%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of 3-nitropicolinaldehyde (500 mg, 3.28 mmol) in EtOH (10 mL) was added Pd/C (50 mg) under nitrogen atmosphere. The reaction mixture was stirred for overnight under hydrogen atmosphere. The reaction mixture was filtered through cilite and washed with EtOH. The filtrate was concentrated in vacuo to give 3-aminopicolinaldehyde (200 mg, 50% yield): 1H NMR (400 MHz, DMSO-d6) δ 7.132 (br s, 2H), 7.217-7.325 (m, 2H), 7.979 (dd, J=1.6 Hz, J=4.0 Hz, 1H), 9.899 (s, 1H); LC-MS (ESI) m/z 123.0 [M+H]+.

후처리

  1. filtrationThe reaction mixture was filtered through cilite
  2. washwashed with EtOH
  3. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-7bc10bd860ce42e69d3338afce772368
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08633313B2

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