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Phenylboronic Acid → 2-(5-(Biphenyl-3-yl)pent-4-ynyl)isoindoline-1,3-dione

HRID 473518
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HRID 473518 반응식
Br[C:2]1[CH:3]=[C:4]([C:8]#[C:9][CH2:10][CH2:11][CH2:12][N:13]2[C:21](=[O:22])[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14]2=[O:23])[CH:5]=[CH:6][CH:7]=1.[C:24]1(B(O)O)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.COCCOC>[C:2]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:7]=[CH:6][CH:5]=[C:4]([C:8]#[C:9][CH2:10][CH2:11][CH2:12][N:13]2[C:21](=[O:22])[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14]2=[O:23])[CH:3]=1
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참가 물질

5

반응물 2

HCID 66827Phenylboronic AcidHCID 672031272-(5-(3-Bromophenyl)pent-4-ynyl)isoindoline-1,3-dione

생성물 1

HCID 672024882-(5-(Biphenyl-3-yl)pent-4-ynyl)isoindoline-1,3-dione

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매HCID 80711,2-Dimethoxyethane용매

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온도
80 °C

실험 절차

2-(5-(3-Bromophenyl)pent-4-ynyl)isoindoline-1,3-dione (0.31 g, 0.84 mmol), phenyl boronic acid (206 mg, 1.68 mmol), and Pd (PPh3)4 (0.23, 0.2 mmol) were taken into DME (5 mL) and stirred at 80° C. for two hours. The reaction was then quenched with saturated NaHCO3 and the resulting mixture extracted with EtOAc, washed with brine, then dried over sodium sulfate and the solvent removed in vacuo. The resulting residue was purified on normal phase chromatography (Heptane/EtOAc) to yield 2-(5-(biphenyl-3-yl)pent-4-ynyl)isoindoline-1,3-dione. MH+ 366.3

후처리

  1. customThe reaction was then quenched with saturated NaHCO3
  2. extractionthe resulting mixture extracted with EtOAc
  3. washwashed with brine
  4. dry with materialdried over sodium sulfate
  5. customthe solvent removed in vacuo
  6. customThe resulting residue was purified on normal phase chromatography (Heptane/EtOAc)

출처 및 근거

ORD 기록
ord-31c8c68df63946318ed47b271f9e3d1e
출처 데이터셋
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08633322B2

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