5'-[(2-Aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate → 5'-[(2-Aminooxyethyl)methylamino]-5'-deoxy-8-phenyladenosine sulfate

HRID 473572

반응식

HRID 473572 반응식
[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].NOCCN(C)C[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2C)[C@H](O)[C@@H]1O.C(OC(=[N:36][O:37][CH2:38][CH2:39][N:40]([CH3:65])[CH2:41][C@H:42]1[O:46][C@@H:45]([N:47]2[C:56]3[N:55]=[CH:54][N:53]=[C:51]([NH2:52])[C:50]=3[N:49]=[C:48]2[C:57]2[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=2)[C@H:44]([OH:63])[C@@H:43]1[OH:64])C)C>>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[NH2:36][O:37][CH2:38][CH2:39][N:40]([CH3:65])[CH2:41][C@H:42]1[O:46][C@@H:45]([N:47]2[C:56]3[N:55]=[CH:54][N:53]=[C:51]([NH2:52])[C:50]=3[N:49]=[C:48]2[C:57]2[CH:58]=[CH:59][CH:60]=[CH:61][CH:62]=2)[C@H:44]([OH:63])[C@@H:43]1[OH:64]

참가 물질

3

반응물 2

HCID 445641755'-[(2-Aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine sulfateHCID 866496705'-Deoxy-5'-[[2-[[(1-ethoxyethylidene)amino]oxy]ethyl]methylamino]-8-phenyladenosine

생성물 1

HCID 445641775'-[(2-Aminooxyethyl)methylamino]-5'-deoxy-8-phenyladenosine sulfate

실험 절차

Compound 7c was prepared by the same procedure as described for the preparation of 7a using 6c (99 mg, 0.20 mmol): yield 57 mg (42%), MS: m/z 416 (M+H)+; 1HNMR (D2O) δ 8.37 (s, 1H, H-2), 7.73-7.76 (m, 2H, 8-phenyl o-H's), 7.60-7.70 (m, 3H, 8-phenyl m- and p-H's), 6.02 (d, 1H, H-1′, J1′,2′=5.7 Hz), 5.25 (t, 1H, H-2′, J2′,3′=4.9 Hz), 4.46-4.54 (bm, 2H, H-3′, 4′), 4.03 (t, 2H, NH2O—CH2), 3.87-4.0 (m, 1H, 5′-CH2), 3.61-3.67 (m, 1H, 5′-CH2), 3.50-3.55 (m, 2H, N(CH3)—CH2), 3.0 (s, 3H, N—CH3); UV λmax, nm, pH 1, 275 (∈ 21,600), pH 7, 275 (∈ 17,100), pH 13, 274.4 (∈ 16,800). Anal. (C19H25N7O4.2.0H2SO4.3H2O) C, H, N, S.

출처 및 근거

ORD 기록
ord-a604155a62a243249e9379a7c8a98918
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637485B2

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