Sulfuric Acid → 5'-[(4-Aminooxybutyl)methylamino]-5'-deoxy-8-oxoadenosine sulfate

참여 물질

역할	이름	HCID	투입량
반응물	Sulfuric Acid	HCID 1118	—
반응물	5'-[(2-Aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate	HCID 44564175	—
반응물	5'-Deoxy-5'-[[4-[[(1-ethoxyethylidene)amino]oxy]butyl]methylamino]-8-oxoadenosine	HCID 86649675	—
생성물	5'-[(4-Aminooxybutyl)methylamino]-5'-deoxy-8-oxoadenosine sulfate	HCID 86649673	—

반응 단계

The procedure was the same as reported above for 7a using 8c (190 mg, 0.41 mmol) and 2N H2SO4 (3 mL). The compound was purified by column chromatography (elution with 4:1:0.5 chloroform:methanol:NH4OH): yield 208 mg (82%), MS: m/z 384 (M+H)+; 1HNMR (DMSO-d6) δ 10.45 (bs, 1H, 8-OH), 8.05 (s, 1H, H-2), 6.58 (bs, 2H, 6-NH2), 5.77 (d, 1H, H-1′, J1′,2′=5.0 Hz), 5.37-5.71 (bm, 2H, O—NH2), 4.83 (t, 1H, H-2′, J2′,3′=4.2 Hz), 4.18-4.29 (m, 2H, H-3′, H-4′), 3.88 (t, 2H, NH2O—CH2), 3.34-3.54 (m, 2H, 5′-CH2), 3.06 (bt, 2H, N(CH3)—CH2), 2.73 (s, 3H, N—CH3), 1.46-1.74 (bm, 4H, NH2OCH2—CH2CH2); UV λmax, nm, pH 1, 263.3 (∈ 12,200), pH 7, 268.9 (∈ 13,600), pH 13, 279.9 (∈ 15,600). Anal. (C15H25N7O5.1.9H2SO4.0.1C2H5OH.2H2O) C, H, N, S.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08637485B2
출처 데이터셋	uspto-grants-2014_01
ORD ID	ord-95f052bdcff748449e9d8a45ec2f5bf9
출처 메모	uspto-grants-2014_01