2-(3,6-dihydro-2H-pyran-4-yl)-3-fluoropyrazine → 2-fluoro-3-(Tetrahydro-2H-pyran-4-yl)pyrazine

HRID 473677노트

반응식

HRID 473677 반응식
[O:1]1[CH2:6][CH:5]=[C:4]([C:7]2[C:12]([F:13])=[N:11][CH:10]=[CH:9][N:8]=2)[CH2:3][CH2:2]1>CCOC(C)=O.[OH-].[OH-].[Pd+2]>[F:13][C:12]1[C:7]([CH:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)=[N:8][CH:9]=[CH:10][N:11]=1

참가 물질

4

반응물 1

HCID 593511782-(3,6-dihydro-2H-pyran-4-yl)-3-fluoropyrazine

생성물 1

HCID 593512282-fluoro-3-(Tetrahydro-2H-pyran-4-yl)pyrazine

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 8857Ethyl Acetate용매

실험 절차

To a round-bottomed flask was added 2-(3,6-dihydro-2H-pyran-4-yl)-3-fluoropyrazine (1.1754 g, 6.52 mmol) and palladium hydroxide on carbon (0.458 g, 0.652 mmol) in EtOAc (21.75 mL). The reaction mixture was flushed with argon and then placed under vacuum three times. A hydrogen balloon was then attached to the reaction. After stirring overnight, the reaction mixture was filtered through celite and concentrated in vacuo to give the title compound. MS (ESI, pos. ion) m/z: 183.1.

후처리

  1. customThe reaction mixture was flushed with argon
  2. customA hydrogen balloon was then attached to the reaction
  3. filtrationthe reaction mixture was filtered through celite and
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-cf8551b3d76b4c059eab820300919940
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637500B2

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