Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → 6-Bromo-1-methyl-1H-indazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 6-Bromo-1H-indazole | HCID 17842471 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 6-Bromo-1-methyl-1H-indazole | HCID 22558675 | — |
반응 단계
6-Bromoindazole (400 mg) was dissolved in methanol (10 mL). To this solution, potassium hydroxide (450 mg) was added followed by methyl iodide (0.50 mL) and the mixture was refluxed for 2.5 h. The reaction was cooled, diluted with diethyl ether, washed with water, brine, dried and concentrated. The product 6-bromo-1-methylindazole (160 mg) was separated from its isomer by Combiflash.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08637497B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-615be3596a7d4ecc8f70f7e5d3a21df5 |
| 출처 메모 | uspto-grants-2014_01 |