Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Promethazine → promethazine dibenzoyl-D-tartrate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Promethazine | HCID 4927 | — |
| 반응물 | Di-benzoyl-d-tartaric acid | HCID 12362977 | — |
| 반응물 | promethazine D-tartrate | HCID 86609044 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | promethazine dibenzoyl-D-tartrate | HCID 131731159 | — |
반응 단계
To prepare promethazine-D-tartrate, promethazine (10 g, 0.035 mol) dissolved in 80 ml acetone was heated in a 60° C. bath while dibenzoyl-D-tartaric acid (12.789 g, 0.036 mol) was added. The resulting clear yellow solution was left at ambient temperature for 3 days (step 2). A heavy precipitate formed, which was filtered off and recrystalized from ethanol four times to give 4.0 g promethazine dibenzoyl-D-tartrate white crystals (step 3).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08637503B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-f0c06199abd84d49a9fcb7be2f20aa78 |
| 출처 메모 | uspto-grants-2014_01 |