Trifluoroacetic acid → 4-(4-Bromophenyl)-5,7-dichloro-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester

HRID 47393

반응식

HRID 47393 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].[CH2:10]([C:12](=O)[C:13]([O-:15])=[O:14])[CH3:11].[Br:17][C:18]1[CH:25]=[CH:24][C:21](C=C)=[CH:20][CH:19]=1.F[C:27](F)(F)[C:28](O)=O>C(#N)C>[CH2:27]([O:15][C:13]([CH:12]1[CH2:10][CH:11]([C:21]2[CH:24]=[CH:25][C:18]([Br:17])=[CH:19][CH:20]=2)[C:3]2[C:4](=[CH:6][C:7]([Cl:9])=[CH:8][C:2]=2[Cl:1])[NH:5]1)=[O:14])[CH3:28]

참가 물질

6

반응물 4

HCID 6422Trifluoroacetic acidHCID 122813,5-DichloroanilineHCID 162634-BromostyreneHCID 35932772-Ketobutyrate

생성물 1

HCID 102742204-(4-Bromophenyl)-5,7-dichloro-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Compound 39 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 4-bromostyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.

출처 및 근거

ORD 기록
ord-f431251f81264fe1985d8880f2e0b70f
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699877B2

연결된 노트

불러오는 중…