Trifluoroacetic acid → 3-Methylazetidine-3-carbonitrile; trifluoroacetic acid

HRID 474003노트

반응식

HRID 474003 반응식
[C:1]([C:3]1([CH3:14])[CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1)#[N:2].[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[CH3:14][C:3]1([C:1]#[N:2])[CH2:6][NH:5][CH2:4]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 56971684tert-Butyl 3-cyano-3-methylazetidine-1-carboxylate

생성물 1

HCID 673862343-Methylazetidine-3-carbonitrile; trifluoroacetic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of tert-butyl 3-cyano-3-methylazetidine-1-carboxylate (30.0 mg, 0.15 mmol) in dichloromethane (5 ml) was added trifluoroacetic acid (2 ml) and the solution stirred at room temperature for 1 hr. The reaction was concentrated and dried under vacuum to give a viscous oil which was used crude in subsequent chemistry.

후처리

  1. concentrationThe reaction was concentrated
  2. customdried under vacuum
  3. customto give a viscous oil which

출처 및 근거

ORD 기록
ord-d1a4ed65e087492d84603c388e007005
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637511B2

반응 노트

불러오는 중…