Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → [4-(3-Cyclopropylpyrazin-2-yl)phenyl]acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | Methyl [4-(3-cyclopropylpyrazin-2-yl)phenyl]acetate | HCID 59535940 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | [4-(3-Cyclopropylpyrazin-2-yl)phenyl]acetic acid | HCID 59535939 | 85% |
반응 단계
To a solution of 0.10 g (0.37 mmol) of methyl [4-(3-cyclopropylpyrazin-2-yl)phenyl]acetate in 0.75 ml of MeOH was added 0.75 mL (0.75 mmol) of 1N LiOH. After 1 h at room temperature, the reaction mixture was acidified with 1 N HCl, extracted twice with ethyl acetate. The combined organic layers were washed with brine. The organic layer was dried over Na2SO4, filtered and concentrated in vacuo to afforded 0.080 g (84%) of [4-(3-cyclopropylpyrazin-2-yl)phenyl]acetic acid. ES-MS M+1=255.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08637513B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-d717518d453149938a13cc4a466f6cf3 |
| 출처 메모 | uspto-grants-2014_01 |