Hydrochloric Acid → [4-(3-Cyclopropylpyrazin-2-yl)phenyl]acetic acid

HRID 474145

반응식

HRID 474145 반응식
[CH:1]1([C:4]2[C:5]([C:10]3[CH:15]=[CH:14][C:13]([CH2:16][C:17]([O:19]C)=[O:18])=[CH:12][CH:11]=3)=[N:6][CH:7]=[CH:8][N:9]=2)[CH2:3][CH2:2]1.[Li+].[OH-].Cl>CO>[CH:1]1([C:4]2[C:5]([C:10]3[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=[O:18])=[CH:12][CH:11]=3)=[N:6][CH:7]=[CH:8][N:9]=2)[CH2:2][CH2:3]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 59535940Methyl [4-(3-cyclopropylpyrazin-2-yl)phenyl]acetate

생성물 1

HCID 59535939[4-(3-Cyclopropylpyrazin-2-yl)phenyl]acetic acid수율 85%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 0.10 g (0.37 mmol) of methyl [4-(3-cyclopropylpyrazin-2-yl)phenyl]acetate in 0.75 ml of MeOH was added 0.75 mL (0.75 mmol) of 1N LiOH. After 1 h at room temperature, the reaction mixture was acidified with 1 N HCl, extracted twice with ethyl acetate. The combined organic layers were washed with brine. The organic layer was dried over Na2SO4, filtered and concentrated in vacuo to afforded 0.080 g (84%) of [4-(3-cyclopropylpyrazin-2-yl)phenyl]acetic acid. ES-MS M+1=255.1.

후처리

  1. extractionextracted twice with ethyl acetate
  2. washThe combined organic layers were washed with brine
  3. dry with materialThe organic layer was dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-d717518d453149938a13cc4a466f6cf3
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637513B2

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