Thionyl Chloride → 5-Bromo-2-(3-(chloromethyl)phenyl)pyrimidine

HRID 474208노트

반응식

HRID 474208 반응식
[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:8]2[CH:9]=[C:10]([CH2:14]O)[CH:11]=[CH:12][CH:13]=2)=[N:6][CH:7]=1.S(Cl)([Cl:18])=O>ClCCl>[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH2:14][Cl:18])[CH:9]=2)=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 59484879(3-(5-Bromopyrimidin-2-yl)phenyl)methanol

생성물 1

HCID 594380475-Bromo-2-(3-(chloromethyl)phenyl)pyrimidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

80 g (302 mmol) of [3-(5-bromopyrimidin-2-yl)phenyl]methanol are suspended in 300 ml of dichloromethane, and 33 ml (453 mmol) of thionyl chloride are slowly added with cooling. The reaction mixture is stirred at room temperature for 3 h. The solvent was distilled off, co-evaporated 3 times with toluene and stirred with diethyl ether:

후처리

  1. temperaturewith cooling
  2. distillationThe solvent was distilled off
  3. stirringco-evaporated 3 times with toluene and stirred with diethyl ether

출처 및 근거

ORD 기록
ord-dccdc4d472954f8aa9071115cb2aeeed
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637518B2

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