Methanol → 2-(4-Methoxy-phenoxy)-5-nitro-benzoic acid methyl ester

HRID 47437노트

반응식

HRID 47437 반응식
[CH3:1][O:2][C:3]1[CH:21]=[CH:20][C:6]([O:7][C:8]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:9]=2[C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[CH3:22]O>S(=O)(=O)(O)O>[CH3:22][O:11][C:10](=[O:12])[C:9]1[CH:13]=[C:14]([N+:17]([O-:19])=[O:18])[CH:15]=[CH:16][C:8]=1[O:7][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:21][CH:20]=1

참가 물질

4

반응물 2

HCID 887MethanolHCID 28008662-(4-methoxyphenoxy)-5-nitrobenzoic acid

생성물 1

HCID 540755342-(4-Methoxy-phenoxy)-5-nitro-benzoic acid methyl ester

시약·촉매·용매 1

HCID 1118Sulfuric Acid촉매

실험 절차

2-(4-Methoxy-phenoxy)-5-nitro-benzoic acid (2.5 g), (DE 2058295) in methanol (75 ml) containing conc. sulfuric acid (3 drops) was boiled for 16 h. Solvent was removed at reduced pressure, the residue dissolved in ethyl acetate and washed with aqueous sodium hydrogen carbonate. The organic phase was dried (Na2SO4) and solvent removed at reduced pressure to give 2-(4-methoxy-phenoxy)-5-nitro-benzoic acid methyl ester (2.50 g). m/z (API+): 304 (MH+).

후처리

  1. customSolvent was removed at reduced pressure
  2. dissolutionthe residue dissolved in ethyl acetate
  3. washwashed with aqueous sodium hydrogen carbonate
  4. dry with materialThe organic phase was dried (Na2SO4) and solvent
  5. customremoved at reduced pressure

출처 및 근거

ORD 기록
ord-fcd65e698cba4ce88f7661c0861eb09c
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699879B1

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