2-(4-Methoxy-phenoxy)-5-nitro-benzoic acid methyl ester → HCID 54346018, 화합물

HRID 47438노트

반응식

HRID 47438 반응식
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[CH:6][C:5]=1[O:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1.[H][H]>CO.[Pd]>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8]([NH2:10])[CH:7]=[CH:6][C:5]=1[O:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1

참가 물질

5

반응물 2

HCID 540755342-(4-Methoxy-phenoxy)-5-nitro-benzoic acid methyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 54346018HCID 54346018, 화합물수율 96.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

The compound of step 1 (2.3 g) in methanol (150 ml) containing 10% Pd/C (0.5 g) was hydrogenated under one atmosphere of hydrogen for 18 h. The mixture was filtered (kieselguhr) and solvent removed from the filtrate under reduced pressure to give the title compound (2.0 g) as a yellow oil. 1H NMR (CDCl3) δ: 3.69 (2H, brs), 3.77 (6H, s), 6.76-6.87 (6H, m), 7.19 (1H, d, J=2.5 Hz).

후처리

  1. filtrationThe mixture was filtered (kieselguhr) and solvent
  2. customremoved from the filtrate under reduced pressure

출처 및 근거

ORD 기록
ord-aaf8ecbfeabc41609627124b2c8edee2
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699879B1

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