Nitric Acid → N-methyl-6-nitro-1,3-benzoxazol-2-amine

반응식

[CH3:1][NH:2][C:3]1[O:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[N+:12]([O-])([OH:14])=[O:13]>>[CH3:1][NH:2][C:3]1[O:4][C:5]2[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:6]=2[N:7]=1

참가 물질

반응물 2

HCID 944Nitric Acid

HCID 590605N-methyl-1,3-benzoxazol-2-amine

생성물 1

HCID 12711466N-methyl-6-nitro-1,3-benzoxazol-2-amine

실험 절차

2-Methylaminobenzoxazole (2.0 g, Hetzheim, Annemarie; Schlaak, G.; Kerstan, Christa., Pharmazie, (1987), 42, 80) was added in portions to conc. nitric acid (15 ml) at room temperature. Stirring was continued over 8 h. The reaction mixture was poured onto crushed ice/sodium hydrogen carbonate with vigorous stirring. The precipitated title compound (1.76 g) was collected by filtration and dried in vacuo at 40° C. m/z (API+): 194 (MH+).

후처리

additionThe reaction mixture was poured
customThe precipitated title compound (1.76 g)
filtrationwas collected by filtration
customdried in vacuo at 40° C. m/z (API+)

출처 및 근거

ORD 기록: ord-943d03d05fe64ca280d2c39889409359
출처 데이터셋: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06699879B1

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