Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclopropanemethanamine → N-cyclopropylmethyl-2-methoxy-5-nitrobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclopropanemethanamine | HCID 75646 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 2-Methoxy-5-nitrobenzoic acid | HCID 284163 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-cyclopropylmethyl-2-methoxy-5-nitrobenzamide | HCID 22745177 | — |
반응 단계
A solution of 2-methoxy-5-nitrobenzoic acid (4.9 g) (Rec. Trav. Chim. Pays-Bas, 1936, 737) and cyclopropylmethylamine (1.75 g) in dimethylformamide was treated with N-hydroxybenzotriazole (0.2 g) and EDC.HCl (4.74 g). The mixture was stirred for 24 h. Saturated sodium hydrogen carbonate was added, the mixture stirred for 3 h and the precipitate collected as the title compound (6.95 g). m/z (API+): 251 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06699879B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-3370e82ed778478a89ecbc5d7a072618 |
| 출처 메모 | uspto-grants-2004_03 |