참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride | HCID 66763358 | — |
| 반응물 | HCID 178506089 | HCID 178506089 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178513604 | HCID 178513604 | — |
반응 단계
33 mg (0.11 mmol) 4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride and 24 mg (0.11 mmol) 2-Chloro-5-trifluoromethyl-1H-benzoimidazole were dissolved in 500 μl DMF and stirred at 100° C. for 15 h. The reaction mixture was directly purified using preparative HPLC. The product was treated with HCl in methanol and concentrated in the SpeedVac.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08637532B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_01 |
|---|
| ORD ID | ord-b73afaaeb5fb4c2298486c853c8e7c6f |
|---|
| 출처 메모 | uspto-grants-2014_01 |
|---|
