4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride → HCID 178513604, 화합물

HRID 474471

반응식

HRID 474471 반응식
Cl.[NH2:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[CH2:6][NH:7][C:8]1[C:17]2[C:12](=[C:13]([C:18]([NH2:20])=[O:19])[CH:14]=[CH:15][CH:16]=2)[N:11]=[CH:10][N:9]=1.Cl[C:25]1[NH:29][C:28]2[CH:30]=[CH:31][C:32]([C:34]([F:37])([F:36])[F:35])=[CH:33][C:27]=2[N:26]=1>CN(C=O)C>[F:37][C:34]([F:35])([F:36])[C:32]1[CH:31]=[CH:30][C:28]2[NH:29][C:25]([NH:2][C:3]3[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=3)[CH2:6][NH:7][C:8]3[C:17]4[C:12](=[C:13]([C:18]([NH2:20])=[O:19])[CH:14]=[CH:15][CH:16]=4)[N:11]=[CH:10][N:9]=3)=[N:26][C:27]=2[CH:33]=1

참가 물질

4

반응물 2

HCID 667633584-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochlorideHCID 178506089HCID 178506089, 화합물

생성물 1

HCID 178513604HCID 178513604, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

33 mg (0.11 mmol) 4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride and 24 mg (0.11 mmol) 2-Chloro-5-trifluoromethyl-1H-benzoimidazole were dissolved in 500 μl DMF and stirred at 100° C. for 15 h. The reaction mixture was directly purified using preparative HPLC. The product was treated with HCl in methanol and concentrated in the SpeedVac.

후처리

  1. customThe reaction mixture was directly purified
  2. additionThe product was treated with HCl in methanol
  3. concentrationconcentrated in the SpeedVac

출처 및 근거

ORD 기록
ord-b73afaaeb5fb4c2298486c853c8e7c6f
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637532B2

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