Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → methyl 4-{[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]amino}-6-iodoquinazoline-8-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | tert-butyl (3S)-3-aminopiperidine-1-carboxylate | HCID 1501975 | — |
| 반응물 | Methyl 4-chloro-6-iodoquinazoline-8-carboxylate | HCID 77231312 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | methyl 4-{[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]amino}-6-iodoquinazoline-8-carboxylate | HCID 66763868 | 14.3% |
반응 단계
Dissolved tert-butyl (35)-3-aminopiperidine-1-carboxylate (632.11 mg; 3.16 mmol; 1.10 eq.) in MeCN (18.00 ml) and TEA (1.00 ml). Added this mixture to methyl 4-chloro-6-iodoquinazoline-8-carboxylate (1000.00 mg; 2.87 mmol; 1.00 eq.). Stirred reaction at room temperature for 45 hours. LCMS indicated M+1=513 present. Diluted reaction with water and 1N NaOH. Filtered the resulting precipitate. Washed with water and dried to give a yellowish solid (210 mg). Carried material on without further purification. LCMS: M+1=513
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08637532B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-e86dd1e0306b49829c7fcbea9a8491cb |
| 출처 메모 | uspto-grants-2014_01 |