methyl (2E)-3-(pyrimidin-5-yl)prop-2-enoate → Methyl 3-(pyrimidin-5-yl)propanoate

HRID 474543노트

반응식

HRID 474543 반응식
[N:1]1[CH:6]=[C:5](/[CH:7]=[CH:8]/[C:9]([O:11][CH3:12])=[O:10])[CH:4]=[N:3][CH:2]=1>CO.[Pd]>[N:1]1[CH:6]=[C:5]([CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:4]=[N:3][CH:2]=1

참가 물질

4

반응물 1

HCID 18470237methyl (2E)-3-(pyrimidin-5-yl)prop-2-enoate

생성물 1

HCID 18470121Methyl 3-(pyrimidin-5-yl)propanoate수율 92.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of methyl (2E)-3-(5-pyrimidinyl)-2-propenoate (19.2 g, 117 mmol) and Pd/C (2 g, 1.879 mmol) in methanol (100 mL) was stirred under H2 at 50° C. overnight. The mixture was filtered through a pad of celite and concentrated to give the crude title compound as yellow oil (18 g, 55.6% yield). LCMS: rt=1.11 min, [M+H+]=167

후처리

  1. filtrationThe mixture was filtered through a pad of celite
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c77d9593e92e4cfab70f3c89c785d9fe
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637536B2

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