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Potassium Carbonate → HCID 178494122, 화합물

HRID 474558
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인쇄 미리보기

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HRID 474558 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11](=[NH:13])[NH2:12])[CH:5]=[CH:6][C:7]=1[F:8].[OH:14]/[CH:15]=[C:16](/[CH2:21][C:22]1[CH:23]=[N:24][C:25]([O:28][CH3:29])=[N:26][CH:27]=1)\[C:17](OC)=O.C([O-])([O-])=O.[K+].[K+]>CN1C(=O)CCC1>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[F:8])[CH2:9][CH2:10][C:11]1[NH:12][CH:17]=[C:16]([CH2:21][C:22]2[CH:23]=[N:24][C:25]([O:28][CH3:29])=[N:26][CH:27]=2)[C:15](=[O:14])[N:13]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

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HCID 11430Potassium CarbonateHCID 67773579(Z)-methyl 3-hydroxy-2-((2-methoxypyrimidin-5-yl)methyl)acrylateHCID 677738673-(3-Bromo-4-fluorophenyl)propanimidamide

생성물 1

HCID 178494122HCID 178494122, 화합물수율 42.8%

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

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온도
130 °C

실험 절차

The mixture of 3-(3-bromo-4-fluorophenyl)propanimidamide (3.28 g, 13.38 mmol), methyl (2Z)-3-hydroxy-2-{[2-(methyloxy)-5-pyrimidinyl]methyl}-2-propenoate (1.5 g, 6.69 mmol) and K2CO3 (2.77 g, 20.07 mmol) in NMP (20 mL) was heated with a microwave reactor at 130° C. for 2 h. The mixture was purified with a reverse phase Biotage to provide the title compound (1.2 g, 40.6% yield). LCMS: rt=2.52 min, [M+H+]=419

후처리

  1. customThe mixture was purified with a reverse phase Biotage

출처 및 근거

ORD 기록
ord-90c89de6ab1a484f941d22a1f286063b
출처 데이터셋
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08637536B2

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