Dimethylformamide → HCID 178526937, 화합물

HRID 47460

반응식

HRID 47460 반응식
[O-:1]CC.[K+].[CH3:5][C:6]1[N:10]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][C:16]=2[C:17]([O:19]CC)=O)[N:9]=[N:8][N:7]=1.CN(C)C=O>C(O)(=O)C>[OH2:1].[N:9]1[N:10]2[C:11]3[C:16]([C:17]([OH:19])=[CH:5][C:6]2=[N:7][N:8]=1)=[CH:15][CH:14]=[N:13][CH:12]=3

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 22172739ethyl 3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylateHCID 23670592Potassium ethoxide

생성물 1

HCID 178526937HCID 178526937, 화합물수율 90.9%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Potassium ethoxide (20.2 g) was added to a mixture of ethyl 3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylate (28 g) and dimethylformamide (280 mL). The reaction mixture was allowed to stir at ambient temperature overnight then poured into cold dilute acetic acid. The resulting precipitate was collected, washed with water and dried to provide 22.4 g of tetrazolo[1,5-a][1,7]naphthyridin-5-ol hydrate as a solid, m.p. 247-248° C. (decomposition). Analysis: Calculated for C8H5N5O: %C, 46.83; %H, 3.44; %N, 34.13. Found: %C, 46.48; %H, 3.42; %N, 34.03.

후처리

  1. customThe resulting precipitate was collected
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-bd0cdde275de498d9a53580003c5b510
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699878B2

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