참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-(4-(4-Chloro-3-(trifluoromethyl)phenoxy)phenyl)ethanamine | HCID 67775548 | — |
| 반응물 | HCID 178494135 | HCID 178494135 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 178494131 | HCID 178494131 | 48.2% |
반응 단계
To the solution of 5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-2-(nitroamino)-4(1H)-pyrimidinone (100 mg, 0.359 mmol) in ethanol (5 mL) was added neat 2-(4-{[4-chloro-3-(trifluoromethyl)-phenyl]oxy}phenyl)ethanamine (189 mg, 0.599 mmol). It was heated with a microwave reactor at 100° C. overnight. Purification via MDAP then afforded the title compound (92 mg, 35.6% yield). LCMS: rt=3.04 min, [M+H+]=532.2
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08637536B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_01 |
|---|
| ORD ID | ord-1c825d4e12414d4899d278edf370d886 |
|---|
| 출처 메모 | uspto-grants-2014_01 |
|---|
