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Potassium Carbonate → HCID 178480214, 화합물

HRID 474833
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HRID 474833 반응식
[C:1](=[NH:23])([O:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)=[CH:8][CH:7]=1)[NH2:2].[CH:24]([CH:26]([CH2:31][C:32]1[CH:33]=[N:34][N:35]([CH3:37])[CH:36]=1)[C:27](OC)=O)=[O:25].C([O-])([O-])=O.[K+].[K+]>CN1C(=O)CCC1>[CH3:37][N:35]1[CH:36]=[C:32]([CH2:31][C:26]2[C:24](=[O:25])[N:23]=[C:1]([O:3][CH2:4][CH2:5][C:6]3[CH:7]=[CH:8][C:9]([O:12][C:13]4[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=4)=[CH:10][CH:11]=3)[NH:2][CH:27]=2)[CH:33]=[N:34]1
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참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 18470567Methyl 2-formyl-3-(1-methyl-1H-pyrazol-4-yl)propanoateHCID 677748222-(4-{[4-(Trifluoromethyl)phenyl]oxy}phenyl)ethyl imidocarbamate

생성물 1

HCID 178480214HCID 178480214, 화합물수율 12.7%

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

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온도
110 °C

실험 절차

To the solution of 2-(4-{[4-(trifluoromethyl)phenyl]oxy}phenyl)ethyl imidocarbamate (50 mg, 0.114 mmol) and methyl 2-formyl-3-(1-methyl-1H-pyrazol-4-yl)propanoate (27 mg, 0.138 mmol) in NMP (1 mL), was added K2CO3 (60 mg, 0.434 mmol). The mixture was heated with a microwave reactor at 110° C. for 1 h. Purification via MDAP then afforded the title compound (6.8 mg, 10.19% yield). LCMS: rt=3.30 min, [M+H+]=471

후처리

  1. customPurification via MDAP

출처 및 근거

ORD 기록
ord-945c05a0ffce477daa932a322f4c6d77
출처 데이터셋
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08637536B2

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